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Document type:
journal article 
Author(s):
Müller, Nicole; Fischer, Julius C; Yabal, Monica; Haas, Tobias; Poeck, Hendrik; Jost, Philipp J 
Title:
XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice. 
Abstract:
Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent. 
Journal title abbreviation:
Eur J Immunol 
Year:
2019 
Journal volume:
49 
Journal issue:
Pages contribution:
504-507 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0014-2980 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie