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Document type:
journal article 
Author(s):
Stangl, Stefan; Foulds, Gemma A; Fellinger, Helena; Pilkington, Geoffrey J; Pockley, A Graham; Multhoff, Gabriele 
Title:
Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody. 
Abstract:
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might serve as a tumor-specific biomarker of aggressive disease. We have previously shown that, in contrast to normal cells, tumor cells present Hsp70 on their plasma membrane. In order to elucidate the role of intracellular and membrane-bound Hsp70 as a potential tumor biomarker in glioblastoma multiforme, herein, we describe protocols for the staining o...    »
 
Journal title abbreviation:
Methods Mol Biol 
Year:
2018 
Journal volume:
1709 
Pages contribution:
307-320 
Language:
eng 
Print-ISSN:
1064-3745 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie