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Document type:
journal article 
Author(s):
Abdullahi, Sarah; Jäkel, Melanie; Behrend, Sabine J; Steiger, Katja; Topping, Geoffrey; Krabbe, Teresa; Colombo, Alessio; Sandig, Volker; Schiergens, Tobias S; Thasler, Wolfgang E; Werner, Jens; Lichtenthaler, Stefan F; Schmid, Roland M; Ebert, Oliver; Altomonte, Jennifer 
Title:
A Novel Chimeric Oncolytic Virus Vector for Improved Safety and Efficacy as a Platform for the Treatment of Hepatocellular Carcinoma. 
Abstract:
Oncolytic viruses represent an exciting new aspect of the evolving field of cancer immunotherapy. We have engineered a novel hybrid vector comprising vesicular stomatitis virus (VSV) and Newcastle disease virus (NDV), named recombinant VSV-NDV (rVSV-NDV), wherein the VSV backbone is conserved but its glycoprotein has been replaced by the hemagglutinin-neuraminidase (HN) and the modified, hyperfusogenic fusion (F) envelope proteins of recombinant NDV. In comparison to wild-type VSV, which kills c...    »
 
Journal title abbreviation:
J Virol 
Year:
2018 
Journal volume:
92 
Journal issue:
23 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-538X 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie