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Document type:
journal article 
Author(s):
Schulze, Sarah; Stöß, Christian; Lu, Miao; Wang, Baocai; Laschinger, Melanie; Steiger, Katja; Altmayr, Felicitas; Friess, Helmut; Hartmann, Daniel; Holzmann, Bernhard; Hüser, Norbert 
Title:
Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy. 
Abstract:
Stimulation of cytosolic nucleic acid sensors of innate immunity by pathogen-derived nucleic acids is important for antimicrobial defence, but stimulation through self-derived nucleic acids may contribute to autoinflammation and cancer. DNA sensing in the cytosol requires the stimulator of interferon genes (STING), while cytosolic RNA sensors use mitochondrial antiviral-signalling protein (MAVS). In a murine model of two-thirds hepatectomy, combined deficiency of MAVS and STING resulted in stron...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2018 
Journal volume:
Journal issue:
Pages contribution:
12271 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie