User: Guest  Login
Document type:
journal article 
Author(s):
Shiow, Lawrence R; Favrais, Geraldine; Schirmer, Lucas; Schang, Anne-Laure; Cipriani, Sara; Andres, Christian; Wright, Jaclyn N; Nobuta, Hiroko; Fleiss, Bobbi; Gressens, Pierre; Rowitch, David H 
Title:
Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury. 
Abstract:
Inflammation is a major risk factor for neonatal white matter injury (NWMI), which is associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest of oligodendrocyte progenitor cells (OPCs) in NWMI, the identity of inflammatory mediators with direct effects on OPCs has been unclear. Here, we investigated downstream effects of pro-inflammatory IL-1? to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter. First,...    »
 
Journal title abbreviation:
Glia 
Year:
2017 
Journal volume:
65 
Journal issue:
12 
Pages contribution:
2024-2037 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0894-1491 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie