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Document type:
journal article 
Author(s):
Geismann, Claudia; Grohmann, Frauke; Dreher, Anita; Häsler, Robert; Rosenstiel, Philip; Legler, Karen; Hauser, Charlotte; Egberts, Jan Hendrik; Sipos, Bence; Schreiber, Stefan; Linkermann, Andreas; Hassan, Zonera; Schneider, Günter; Schäfer, Heiner; Arlt, Alexander 
Title:
Role of CCL20 mediated immune cell recruitment in NF-?B mediated TRAIL resistance of pancreatic cancer. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers. From a clinical view, the transcription factor NF-?B is of particular importance, since this pathway confers apoptosis resistance and limits drug efficacy. Whereas the role of the most abundant NF-?B subunit p65/RelA in therapeutic resistance is well documented, only little knowledge of the RelA downstream targets and their functional relevance in TRAIL mediated apoptosis in PDAC is available. In the present study T...    »
 
Journal title abbreviation:
Biochim Biophys Acta 
Year:
2017 
Journal volume:
1864 
Journal issue:
Pages contribution:
782-796 
Language:
eng 
Print-ISSN:
0006-3002 
TUM Institution:
Klinik und Poliklinik für Innere Medizin II