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Document type:
journal article 
Author(s):
Lenk, Lennart; Pein, Maren; Will, Olga; Gomez, Beatriz; Viol, Fabrice; Hauser, Charlotte; Egberts, Jan-Hendrik; Gundlach, Jan-Paul; Helm, Ole; Tiwari, Sanjay; Weiskirchen, Ralf; Rose-John, Stefan; Röcken, Christoph; Mikulits, Wolfgang; Wenzel, Patrick; Schneider, Günter; Saur, Dieter; Schäfer, Heiner; Sebens, Susanne 
Title:
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed when liver metastases already emerged. This study elucidated the impact of hepatic stromal cells on growth behavior of premalignant and malignant pancreatic ductal epithelial cells (PDECs). Liver sections of tumor-bearing KPC mice comprised micrometastases displaying low proliferation located in an unobtrusive hepatic microenvironment whereas macrometastases containing more proliferating cells were surrounded by hepatic myofibroblasts (H...    »
 
Journal title abbreviation:
Oncoimmunology 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
e1368603 
Language:
eng 
Print-ISSN:
2162-4011 
TUM Institution:
Klinik und Poliklinik für Innere Medizin II; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)