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Document type:
journal article 
Author(s):
Manfrini, Nicola; Ricciardi, Sara; Miluzio, Annarita; Fedeli, Maya; Scagliola, Alessandra; Gallo, Simone; Brina, Daniela; Adler, Thure; Busch, Dirk H; Gailus-Durner, Valerie; Fuchs, Helmut; Hrab? de Angelis, Martin; Biffo, Stefano 
Title:
High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4 T cells in both mice and humans. 
Abstract:
Eukaryotic Initiation Factor 6 (eIF6) is required for 60S ribosomal subunit biogenesis and efficient initiation of translation. Intriguingly, in both mice and humans, endogenous levels of eIF6 are detrimental as they act as tumor and obesity facilitators, raising the question on the evolutionary pressure that maintains high eIF6 levels. Here we show that, in mice and humans, high levels of eIF6 are required for proper immune functions. First, eIF6 heterozygous (het) mice show an increased mortal...    »
 
Journal title abbreviation:
Dev Comp Immunol 
Year:
2017 
Journal volume:
77 
Pages contribution:
69-76 
Language:
eng 
Print-ISSN:
0145-305X 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene