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Document type:
journal article 
Author(s):
Herwerth, M; Kalluri, SR; Srivastava, R; Kleele, T; Kenet, S; Illes, Z; Merkler, D; Bennett, JL; Misgeld, T; Hemmer, B 
Title:
In Vivo Imaging Reveals Rapid Astrocyte Depletion and Axon Damage in a Model of Neuromyelitis Optica-Related Pathology 
Abstract:
Objective: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry immunoglobulin G autoantibodies against aquaporin-4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes by complement, but NMO histopathology also show...    »
 
Journal title abbreviation:
Ann Neurol 
Year:
2016 
Journal volume:
79 
Journal issue:
Pages contribution:
794-805 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0364-5134 
TUM Institution:
Neurologische Klinik und Poliklinik; Institut für Zellbiologie des Nervensystems