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Document type:
journal article 
Author(s):
Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela; Malo, Antje; Valls, Roser Marin; Wang, Fan; Reinert, Line S; Dagnaes-Hansen, Frederik; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm; Protzer, Ulrike; Paludan, Søren R 
Title:
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. 
Abstract:
Hepatitis B virus (HBV) is a major human pathogen, and about one third of the global population will be exposed to the virus in their lifetime. HBV infects hepatocytes, where it replicates its DNA and infection can lead to acute and chronic hepatitis with a high risk of liver cirrhosis and hepatocellular carcinoma. Despite this, there is limited understanding of how HBV establishes chronic infections. In recent years it has emerged that foreign DNA potently stimulates the innate immune response,...    »
 
Journal title abbreviation:
Hepatology 
Year:
2016 
Journal volume:
64 
Journal issue:
Pages contribution:
746-59 
Language:
eng 
Print-ISSN:
0270-9139 
TUM Institution:
Institut für Virologie