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Document type:
Journal Article; Article 
Author(s):
Backes, Simone; Jäger, Clemens; Dembek, Claudia J; Kosinska, Anna D; Bauer, Tanja; Stephan, Ann-Sophie; Di?lers, Andris; Mutwiri, George; Busch, Dirk H; Babiuk, Lorne A; Gasteiger, Georg; Protzer, Ulrike 
Title:
Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice. 
Abstract:
Therapeutic vaccination is a novel treatment approach for chronic hepatitis B, but only had limited success so far. We hypothesized that optimized vaccination schemes have increased immunogenicity, and aimed at increasing therapeutic hepatitis B vaccine efficacy.Modified Vaccinia virus Ankara (MVA) expressing hepatitis B virus (HBV) antigens was used to boost protein-prime vaccinations in wildtype and HBV-transgenic (HBVtg) mice.Protein-prime/MVA-boost vaccination was able to overcome HBV-specif...    »
 
Journal title abbreviation:
Vaccine 
Year:
2016 
Journal volume:
34 
Journal issue:
Pages contribution:
923-32 
Language:
eng 
Print-ISSN:
0264-410X 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie