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Document type:
journal article 
Author(s):
Ovsepian, Saak V; LeBerre, Marie; Steuber, Volker; O'Leary, Valerie B; Leibold, Christian; Oliver Dolly, J 
Title:
Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease. 
Abstract:
The diversity of pore-forming subunits of KV1 channels (KV1.1-KV1.8) affords their physiological versatility and predicts a range of functional impairments resulting from genetic aberrations. Curiously, identified so far human neurological conditions associated with dysfunctions of KV1 channels have been linked exclusively to mutations in the KCNA1 gene encoding for the KV1.1 subunit. The absence of phenotypes related to irregularities in other subunits, including the prevalent KV1.2 subunit of...    »
 
Journal title abbreviation:
Pharmacol Ther 
Year:
2016 
Journal volume:
159 
Pages contribution:
93-101 
Language:
eng 
Print-ISSN:
0163-7258 
TUM Institution:
Lehrstuhl für Biologische Bildgebung