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Document type:
journal article 
Author(s):
Ramanujam, Deepak; Sassi, Yassine; Laggerbauer, Bernhard; Engelhardt, Stefan 
Title:
Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart. 
Abstract:
Systemic inhibition of miR-21 has proven effective against myocardial fibrosis and dysfunction, while studies in cardiac myocytes suggested a protective role in this cell type. Considering potential implications for therapy, we aimed to determine the cell fraction where miR-21 exerts its pathological activity. We developed a viral vector-based strategy for gene targeting of nonmyocyte cardiac cells in vivo and compared global to cardiac myocyte-specific and nonmyocyte-specific deletion of miR-21...    »
 
Journal title abbreviation:
Mol Ther 
Year:
2016 
Journal volume:
24 
Journal issue:
11 
Pages contribution:
1939-1948 
Language:
eng 
Print-ISSN:
1525-0016 
TUM Institution:
Institut für Pharmakologie und Toxikologie