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Document type:
journal article 
Author(s):
Regn, Michael; Laggerbauer, Bernhard; Jentzsch, Claudia; Ramanujam, Deepak; Ahles, Andrea; Sichler, Sonja; Calzada-Wack, Julia; Koenen, Rory R; Braun, Attila; Nieswandt, Bernhard; Engelhardt, Stefan 
Title:
Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. 
Abstract:
A key response of the myocardium to stress is the secretion of factors with paracrine or endocrine function. Intriguing in this respect is peptidase inhibitor 16 (PI16), a member of the CAP family of proteins which we found to be highly upregulated in cardiac disease. Up to this point, the mechanism of action and physiological function of PI16 remained elusive. Here, we show that PI16 is predominantly expressed by cardiac fibroblasts, which expose PI16 to the interstitium via a glycophosphatidyl...    »
 
Journal title abbreviation:
J Mol Cell Cardiol 
Year:
2016 
Journal volume:
99 
Pages contribution:
57-64 
Language:
eng 
Print-ISSN:
0022-2828 
TUM Institution:
Institut für Pharmakologie und Toxikologie