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journal article 
Eden, Matthias; Meder, Benjamin; Völkers, Mirko; Poomvanicha, Montatip; Domes, Katrin; Branchereau, M; Marck, P; Will, Rainer; Bernt, Alexander; Rangrez, Ashraf; Busch, Matthias; German Mouse Clinic Consortium; Hrab? de Angelis, Martin; Heymes, Christophe; Rottbauer, Wolfgang; Most, Patrick; Hofmann, Franz; Frey, Norbert; Adler, Thure; Busch, Dirk H; Antonio Aguilar-Pimentel, Juan; Ollert, Markus; Götz, Alexander; Schulz, Holger; Prehn, Cornelia; Adamski, Jerzy; Becker, Lore; Klopstock, Thomas;...    »
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. 
Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel. Knockdown of Myoscape in cardiomyocytes decreases calcium transients associated with smaller Ca(2+) amplitudes and a lower diastolic Ca(2+) content. Likewise, L-type calcium channel currents are significantly diminished on Myoscape ablation, and downregulation of Myoscape significantly reduces con...    »
Journal title abbreviation:
Nat Commun 
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TUM Institution:
Institut für Pharmakologie und Toxikologie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Molekulare Allergologie und Umweltforschung