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Title:

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.

Document type:
Journal Article; Article
Author(s):
Eden, Matthias; Meder, Benjamin; Völkers, Mirko; Poomvanicha, Montatip; Domes, Katrin; Branchereau, M; Marck, P; Will, Rainer; Bernt, Alexander; Rangrez, Ashraf; Busch, Matthias; Hrab? de Angelis, Martin; Heymes, Christophe; Rottbauer, Wolfgang; Most, Patrick; Hofmann, Franz; Frey, Norbert
Abstract:
Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel. Knockdown of Myoscape in cardiomyocytes decreases calcium transients associated with smaller Ca(2+) amplitudes and a lower diastolic Ca(2+) content. Likewise, L-type calcium channel currents are significantly diminished on Myoscape ablation, and downregulation of Myoscape significantly reduces con...     »
Journal title abbreviation:
Nat Commun
Year:
2016
Journal volume:
7
Pages contribution:
11317
Language:
eng
Fulltext / DOI:
doi:15.13155/ncomms11317
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27122098
Print-ISSN:
2041-1723
TUM Institution:
Institut für Pharmakologie und Toxikologie
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