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Document type:
journal article 
Author(s):
Czugala, Marta; Mykhaylyk, Olga; Böhler, Philip; Onderka, Jasmine; Stork, Björn; Wesselborg, Sebastian; Kruse, Friedrich E; Plank, Christian; Singer, Bernhard B; Fuchsluger, Thomas A 
Title:
Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles. 
Abstract:
To develop a safe and efficient method for targeted, anti-apoptotic gene therapy of corneal endothelial cells (CECs).Magnetofection (MF), a combination of lipofection with magnetic nanoparticles (MNPs; PEI-Mag2, SO-Mag5, PalD1-Mag1), was tested in human CECs and in explanted human corneas. Effects on cell viability and function were investigated. Immunocompatibility was assessed in human peripheral blood mononuclear cells.Silica iron-oxide MNPs (SO-Mag5) combined with X-tremeGENE-HP achieved hi...    »
 
Journal title abbreviation:
Nanomedicine (Lond) 
Year:
2016 
Journal volume:
11 
Journal issue:
14 
Pages contribution:
1787-800 
Language:
eng 
Print-ISSN:
1743-5889 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung