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Dokumenttyp:
journal article 
Autor(en):
Vogel, Arndt; Kasper, Stefan; Bitzer, Michael; Block, Andreas; Sinn, Marianne; Schulze-Bergkamen, Henning; Moehler, Markus; Pfarr, Nicole; Endris, Volker; Goeppert, Benjamin; Merx, Kirsten; Schnoy, Elisabeth; Siveke, Jens T; Michl, Patrick; Waldschmidt, Dirk; Kuhlmann, Jan; Geissler, Michael; Kahl, Christoph; Evenkamp, Ralf; Schmidt, Torben; Kuhlmann, Alexander; Weichert, Wilko; Kubicka, Stefan 
Titel:
PICCA study: panitumumab in combination with cisplatin/gemcitabine chemotherapy in KRAS wild-type patients with biliary cancer-a randomised biomarker-driven clinical phase II AIO study. 
Abstract:
Combination chemotherapy has shown benefit in the treatment of biliary cancer and further improvements might be achieved by the addition of a biological agent. We report here the effect of chemotherapy with the monoclonal EGFR antibody panitumumab as therapy for KRAS wild-type biliary cancer.Patients with advanced biliary tract cancer were randomised (2:1) to receive cisplatin 25 mg/m and gemcitabine 1000 mg/m on day 1 and day 8/q3w with (arm A) or without panitumumab (arm B; 9 mg/kg BW, i.v q3...    »
 
Zeitschriftentitel:
Eur J Cancer 
Jahr:
2018 
Band / Volume:
92 
Seitenangaben Beitrag:
11-19 
Sprache:
eng 
Print-ISSN:
0959-8049 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie