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Dokumenttyp:
journal article 
Autor(en):
Jabs, Markus; Rose, Adam J; Lehmann, Lorenz H; Taylor, Jacqueline; Moll, Iris; Sijmonsma, Tjeerd P; Herberich, Stefanie E; Sauer, Sven W; Poschet, Gernot; Federico, Giuseppina; Mogler, Carolin; Weis, Eva-Maria; Augustin, Hellmut G; Yan, Minhong; Gretz, Norbert; Schmid, Roland M; Adams, Ralf H; Gröne, Hermann-Joseph; Hell, Rüdiger; Okun, Jürgen G; Backs, Johannes; Nawroth, Peter P; Herzig, Stephan; Fischer, Andreas 
Titel:
Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart. 
Abstract:
Nutrients are transported through endothelial cells before being metabolized in muscle cells. However, little is known about the regulation of endothelial transport processes. Notch signaling is a critical regulator of metabolism and angiogenesis during development. Here, we studied how genetic and pharmacological manipulation of endothelial Notch signaling in adult mice affects endothelial fatty acid transport, cardiac angiogenesis, and heart function.Endothelial-specific Notch inhibition was a...    »
 
Zeitschriftentitel:
Circulation 
Jahr:
2018 
Band / Volume:
137 
Heft / Issue:
24 
Seitenangaben Beitrag:
2592-2608 
Sprache:
eng 
Print-ISSN:
0009-7322 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie