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Dokumenttyp:
journal article 
Autor(en):
Möller, Leona; Kassubek, Jan; Südmeyer, Martin; Hilker, Rüdiger; Hattingen, Elke; Egger, Karl; Amtage, Florian; Pinkhardt, Elmar H; Respondek, Gesine; Stamelou, Maria; Möller, Franz; Schnitzler, Alfons; Oertel, Wolfgang H; Knake, Susanne; Huppertz, Hans-Jürgen; Höglinger, Günter U 
Titel:
Manual MRI morphometry in Parkinsonian syndromes. 
Abstract:
Several morphometric magnetic resonance imaging parameters may serve for differential diagnosis of parkinsonism. The objective of this study was to identify which performs best in clinical routine.We acquired multicentric magnetization-prepared rapid gradient echo sequences in patients with Parkinson's disease (n=204), progressive supranuclear palsy (n=106), multiple system atrophy-cerebellar, (n = 21); multiple system atrophy-parkinsonian (n = 60), and healthy controls (n = 73), performed manual planimetric measurements, and calculated receiver operator characteristics with leave-one-out cross-validation to propose cutoff values.The midsagittal midbrain area was reduced in PSP versus all other groups (P< 0.001). The midsagittal pons area was reduced in MSA-cerebellar, MSA-parkinsonian, and PSP versus PD patients and healthy controls (P< 0.001). The midbrain/pons area ratio was lower in PSP (P< 0.001) and higher in MSA-cerebellar and MSA-parkinsonian versus PD and PSP (P< 0.001).The midsagittal midbrain area most reliably identified PSP, the midsagittal pons area MSA-cerebellar. The midbrain/pons area ratio differentiated MSA-cerebellar and PSP better than the magnetic resonance-Parkinson index. © 2017 International Parkinson and Movement Disorder Society. 
Zeitschriftentitel:
Mov Disord 
Jahr:
2017 
Band / Volume:
32 
Heft / Issue:
Seitenangaben Beitrag:
778-782 
Sprache:
eng 
Print-ISSN:
0885-3185 
TUM Einrichtung:
Neurologische Klinik und Poliklinik