User: Guest  Login
Document type:
Zeitschriftenaufsatz 
Author(s):
Frejno, Martin; Zenezini Chiozzi, Riccardo; Wilhelm, Mathias; Koch, Heiner; Zheng, Runsheng; Klaeger, Susan; Ruprecht, Benjamin; Meng, Chen; Kramer, Karl; Jarzab, Anna; Heinzlmeir, Stephanie; Johnstone, Elaine; Domingo, Enric; Kerr, David; Jesinghaus, Moritz; Slotta‐Huspenina, Julia; Weichert, Wilko; Knapp, Stefan; Feller, Stephan M; Kuster, Bernhard 
Title:
Pharmacoproteomic characterisation of human colon and rectal cancer 
Abstract:
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome‐guided pre‐clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of each tumo...    »
 
Journal title:
Molecular Systems Biology 
Year:
2017 
Journal volume:
13 
Journal issue:
11 
Pages contribution:
951 
Fulltext / DOI:
Publisher:
EMBO 
E-ISSN:
1744-42921744-42921744-4292 
Date of publication:
01.11.2017