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Dokumenttyp:
journal article 
Autor(en):
Jäkel, Cornelia; Bergmann, Frank; Toth, Reka; Assenov, Yassen; van der Duin, Daniel; Strobel, Oliver; Hank, Thomas; Klöppel, Günter; Dorrell, Craig; Grompe, Markus; Moss, Joshua; Dor, Yuval; Schirmacher, Peter; Plass, Christoph; Popanda, Odilia; Schmezer, Peter 
Titel:
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability. 
Abstract:
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppr...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2017 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1323 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie