User: Guest  Login
Document type:
journal article 
Author(s):
Jäkel, Cornelia; Bergmann, Frank; Toth, Reka; Assenov, Yassen; van der Duin, Daniel; Strobel, Oliver; Hank, Thomas; Klöppel, Günter; Dorrell, Craig; Grompe, Markus; Moss, Joshua; Dor, Yuval; Schirmacher, Peter; Plass, Christoph; Popanda, Odilia; Schmezer, Peter 
Title:
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability. 
Abstract:
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppr...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
1323 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie