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Document type:
Comparative Study; Controlled Clinical Trial; Journal Article; Article 
Author(s):
Maier, M; Abraham, S; Frank, C; Lohmann, C P; Feucht, N 
Title:
[Pharmaological vitreolysis with ocriplasmin as a treatment option for symptomatic focal vitreomacular traction with or without macular holes (<=400 ?m) compared to tranconjunctival vitrectomy]. 
Abstract:
To evaluate the resolution rate in patients with symptomatic vitreomacular traction (VMT) <= 1500 ?m with or without macular holes <= 400 ?m after therapy with intravitreal ocriplasmin (Jetrea®) injections in a clinical setting in comparison to transconjunctival vitrectomy.We examined 21 eyes of 21 consecutive patients with vitreomacular traction with or without macular holes who underwent intravitreal injection of 0.1 ml ocriplasmin and we retrospectively reviewed 18 eyes of 18 patients with VMT with or without FTMH who underwent 23-gauge vitrectomy.Vitreomacular traction resolved in 15 of 21 eyes treated with ocriplasmin after 6 month (71 %) compared to 100 % of eyes treated by vitrectomy. Of the 5 eyes that initially presented FTMH with VMT in the ocriplasmin group, 2 were closed 1 month after ocriplasmin treatment. The remaining 3 had vitrectomy and closed thereafter. Best corrected visual acuity was 0.38 ± 0.23 LogMAR at baseline, improving to 0.34 ± 0.24 LogMAR at 6 months after ocriplasmin treatment. Best corrected visual acuity in the vitrectomy group improved from 0.55 ± 0.29 LogMAR before operation to 0.53 ± 0.51 LogMAR 6 months postoperatively. Foveal thickness was 355.95 ± 114.53 ?m at baseline, reducing to 277.77 ± 40.26 ?m at 6 months after ocriplasmin treatment. Foveal thickness of eyes that underwent vitrectomy was 494.61 ± 126.02 ?m at baseline, decreasing to 330.2 ± 88.85 ?m 6 months postoperatively.When traction is <= 1500 ?m, enzymatic vitreolysis with ocriplasmin is a therapeutic option. In the presence of VMT >1500 ?m or ERM, surgical treatment with vitrectomy is associated with better outcomes. In small macular holes with VMT and in the absence of ERM, enzymatic vitreolysis with ocriplasmin is an option. In cases of holes >400 ?m, or in the absence of evident VMT, or in the presence of ERM, vitrectomy is the first choice. 
Journal title abbreviation:
Ophthalmologe 
Year:
2017 
Journal volume:
114 
Journal issue:
Pages contribution:
148-154 
Language:
de 
Print-ISSN:
0941-293X 
TUM Institution:
Klinik und Poliklinik für Augenheilkunde