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Dokumenttyp:
journal article 
Autor(en):
Urban, Christian; Buck, Achim; Siveke, Jens T; Lordick, Florian; Luber, Birgit; Walch, Axel; Aichler, Michaela 
Titel:
PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI. 
Abstract:
An alcohol-based non-crosslinking tissue fixative, PAXgene Tissue System, has been proposed as alternative fixation method to formalin, providing superior and morphological preservation. To date, metabolites have not been assessed in PAXgene-fixed tissues. The study focuses on a comparison between PAXgene and standard formalin fixation for metabolomic analysis by MALDI mass spectrometry imaging. Therefore, fifty-six samples from seven mice organs were fixed with PAXgene (PFPE) or formalin (FFPE)...    »
 
Zeitschriftentitel:
Biochim Biophys Acta 
Jahr:
2018 
Band / Volume:
1862 
Heft / Issue:
Seitenangaben Beitrag:
51-60 
Sprache:
eng 
Print-ISSN:
0006-3002 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie