User: Guest  Login
Document type:
journal article 
Author(s):
Kowarik, Markus C; Astling, David; Gasperi, Christiane; Wemlinger, Scott; Schumann, Hannah; Dzieciatkowska, Monika; Ritchie, Alanna M; Hemmer, Bernhard; Owens, Gregory P; Bennett, Jeffrey L 
Title:
CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder. 
Abstract:
Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system (CNS) targeted against aquaporin-4 (AQP4). The origin and trafficking of AQP4-specific B cells in NMOSD remains unknown.Peripheral (n = 7) and splenic B cells (n = 1) recovered from seven NMOSD patients were sorted into plasmablasts, naïve, memory, and CD27-IgD- double negative (DN) B cells, and variable heavy chain (VH) transcriptome sequences were generated by deep sequencing. Periphe...    »
 
Journal title abbreviation:
Annals of clinical and translational neurology 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
369-380 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2328-9503 
TUM Institution:
Neurologische Klinik und Poliklinik