Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Yusufi, Nahid; Mall, Sabine; Bianchi, Henrique de Oliveira; Steiger, Katja; Reder, Sybille; Klar, Richard; Audehm, Stefan; Mustafa, Mona; Nekolla, Stephan; Peschel, Christian; Schwaiger, Markus; Krackhardt, Angela M; D Alessandria, Calogero 
Titel:
In-depth Characterization of a TCR-specific Tracer for Sensitive Detection of Tumor-directed Transgenic T Cells by Immuno-PET. 
Abstract:
A number of different technologies have been developed to monitor in vivo the distribution of gene-modified T cells used in immunotherapy. Nevertheless, in-depth characterization of novel approaches with respect to sensitivity and clinical applicability are so far missing. We have previously described a novel method to track engineered human T cells in tumors using (89)Zr-Df-aTCRmu-F(ab')2 targeting the murinized part of the TCR beta domain (TCRmu) of a transgenic TCR. Here, we performed an in-d...    »
 
Zeitschriftentitel:
Theranostics 
Jahr:
2017 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
2402-2416 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie