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Document type:
Zeitschriftenaufsatz 
Author(s):
Balogh, Dóra; Dahmen, Maria; Stahl, Matthias; Poreba, Marcin; Gersch, Malte; Drag, Marcin; Sieber, Stephan A. 
Title:
Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes 
Abstract:
Caseinolytic proteases (ClpP) are important for recognition and controlled degradation of damaged proteins. While the majority of bacterial organisms utilize only a single ClpP, Listeria monocytogenes expresses two isoforms (LmClpP1 and LmClpP2). LmClpPs assemble into either a LmClpP2 homocomplex or a LmClpP1/2 heterooligomeric complex. The heterocomplex in association with the chaperone ClpX, exhibits a boost in proteolytic activity for unknown reasons. Here, we use a combined chemical and bioc...    »
 
Journal title:
Chemical science 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
1592-1600 
Publisher:
Royal Society of Chemistry (RSC) 
Print-ISSN:
2041-6520 
E-ISSN:
2041-6539