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Document type:
journal article 
Author(s):
Lichtmannegger, Josef; Leitzinger, Christin; Wimmer, Ralf; Schmitt, Sabine; Schulz, Sabine; Kabiri, Yaschar; Eberhagen, Carola; Rieder, Tamara; Janik, Dirk; Neff, Frauke; Straub, Beate K; Schirmacher, Peter; DiSpirito, Alan A; Bandow, Nathan; Baral, Bipin S; Flatley, Andrew; Kremmer, Elisabeth; Denk, Gerald; Reiter, Florian P; Hohenester, Simon; Eckardt-Schupp, Friedericke; Dencher, Norbert A; Adamski, Jerzy; Sauer, Vanessa; Niemietz, Christoph; Schmidt, Hartmut H J; Merle, Uta; Gotthardt, Danie...    »
 
Title:
Methanobactin reverses acute liver failure in a rat model of Wilson disease. 
Abstract:
In Wilson disease (WD), functional loss of ATPase copper-transporting ? (ATP7B) impairs biliary copper excretion, leading to excessive copper accumulation in the liver and fulminant hepatitis. Current US Food and Drug Administration- and European Medicines Agency-approved pharmacological treatments usually fail to restore copper homeostasis in patients with WD who have progressed to acute liver failure, leaving liver transplantation as the only viable treatment option. Here, we investigated the...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2016 
Journal volume:
126 
Journal issue:
Pages contribution:
2721-35 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0021-9738 
TUM Institution:
Institut für Toxikologie und Umwelthygiene