Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Lichtmannegger, Josef; Leitzinger, Christin; Wimmer, Ralf; Schmitt, Sabine; Schulz, Sabine; Kabiri, Yaschar; Eberhagen, Carola; Rieder, Tamara; Janik, Dirk; Neff, Frauke; Straub, Beate K; Schirmacher, Peter; DiSpirito, Alan A; Bandow, Nathan; Baral, Bipin S; Flatley, Andrew; Kremmer, Elisabeth; Denk, Gerald; Reiter, Florian P; Hohenester, Simon; Eckardt-Schupp, Friedericke; Dencher, Norbert A; Adamski, Jerzy; Sauer, Vanessa; Niemietz, Christoph; Schmidt, Hartmut H J; Merle, Uta; Gotthardt, Danie...    »
 
Titel:
Methanobactin reverses acute liver failure in a rat model of Wilson disease. 
Abstract:
In Wilson disease (WD), functional loss of ATPase copper-transporting ? (ATP7B) impairs biliary copper excretion, leading to excessive copper accumulation in the liver and fulminant hepatitis. Current US Food and Drug Administration- and European Medicines Agency-approved pharmacological treatments usually fail to restore copper homeostasis in patients with WD who have progressed to acute liver failure, leaving liver transplantation as the only viable treatment option. Here, we investigated the...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2016 
Band / Volume:
126 
Heft / Issue:
Seitenangaben Beitrag:
2721-35 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene