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Dokumenttyp:
journal article 
Autor(en):
Klar, Kathrin; Perchermeier, Sophie; Bhattacharjee, Sonakshi; Harb, Hani; Adler, Thure; Istvanffy, Rouzanna; Loffredo-Verde, Eva; R A Oostendorp, Robert; Renz, Harald; Prazeres da Costa, Clarissa 
Titel:
Chronic schistosomiasis during pregnancy epigenetically reprograms T-cell differentiation in offspring of infected mothers. 
Abstract:
Schistosomiasis is a nontransplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether in utero exposure to chronic schistosome infection (Reg phase) in mice affects B-cell and T-cell development. Therefore, we focused our analyses on T-cell differentiation capacity induced by epigenetic changes in promoter regions of signature cytokines in offspring. Here, we show that naïve T cells from offspring of sch...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2017 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
841-847 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik