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Dokumenttyp:
journal article 
Autor(en):
Müller, T A; Grundler, R; Istvanffy, R; Rudelius, M; Hennighausen, L; Illert, A L; Duyster, J 
Titel:
Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype. 
Abstract:
Mutations that activate FMS-like tyrosine kinase 3 (FLT3) are frequent occurrences in acute myeloid leukemia. Two distinct types of mutations have been described: internal duplication of the juxtamembranous domain (ITD) and point mutations of the tyrosine kinase domain (TKD). Although both mutations lead to constitutive FLT3 signaling, only FLT3-ITD strongly activates signal transducer and activator of transcription 5 (STAT5). In a murine transplantation model, FLT3-ITD induces a myeloproliferat...    »
 
Zeitschriftentitel:
Leukemia 
Jahr:
2016 
Band / Volume:
30 
Heft / Issue:
Seitenangaben Beitrag:
1725-33 
Sprache:
eng 
Print-ISSN:
0887-6924 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik