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Document type:
Zeitschriftenaufsatz 
Author(s):
Ruprecht, Benjamin; Zaal, Esther A.; Zecha, Jana; Wu, Wei; Berkers, Celia R.; Kuster, Bernhard; Lemeer, Simone 
Title:
Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis 
Abstract:
HER2/ERBB2–overexpressing breast cancers targeted effectively by the small-molecule kinase inhibitor lapatinib frequently acquire resistance to this drug. In this study, we employed explorative mass spectrometry to profile proteome, kinome, and phosphoproteome changes in an established model of lapatinib resistance to systematically investigate initial inhibitor response and subsequent reprogramming in resistance. The resulting dataset, which collectively contains quantitative data for >7,800 pr...    »
 
Journal title:
Cancer Research 
Year:
2017 
Journal volume:
77 
Journal issue:
Pages contribution:
1842-1853 
Publisher:
American Association for Cancer Research (AACR) 
E-ISSN:
0008-54721538-7445 
Date of publication:
16.02.2017