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Document type:
journal article 
Author(s):
Emdin, Connor A; Khera, Amit V; Natarajan, Pradeep; Klarin, Derek; Won, Hong-Hee; Peloso, Gina M; Stitziel, Nathan O; Nomura, Akihiro; Zekavat, Seyedeh M; Bick, Alexander G; Gupta, Namrata; Asselta, Rosanna; Duga, Stefano; Merlini, Piera Angelica; Correa, Adolfo; Kessler, Thorsten; Wilson, James G; Bown, Matthew J; Hall, Alistair S; Braund, Peter S; Samani, Nilesh J; Schunkert, Heribert; Marrugat, Jaume; Elosua, Roberto; McPherson, Ruth; Farrall, Martin; Watkins, Hugh; Willer, Cristen; Abecasis,...    »
 
Title:
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. 
Abstract:
Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) levels has emerged as a therapeutic strategy. Beyond target identification, human genetics may contribute to the development of new therapies by defining the full spectrum of beneficial and adverse consequences and by developing a dose-response curve of target perturbation.The goal of this study was...    »
 
Journal title abbreviation:
J Am Coll Cardiol 
Year:
2016 
Journal volume:
68 
Journal issue:
25 
Pages contribution:
2761-2772 
Language:
eng 
Print-ISSN:
0735-1097 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen