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Dokumenttyp:
journal article 
Autor(en):
Zanoni, Paolo; Khetarpal, Sumeet A; Larach, Daniel B; Hancock-Cerutti, William F; Millar, John S; Cuchel, Marina; DerOhannessian, Stephanie; Kontush, Anatol; Surendran, Praveen; Saleheen, Danish; Trompet, Stella; Jukema, J Wouter; De Craen, Anton; Deloukas, Panos; Sattar, Naveed; Ford, Ian; Packard, Chris; Majumder, Abdullah al Shafi; Alam, Dewan S; Di Angelantonio, Emanuele; Abecasis, Goncalo; Chowdhury, Rajiv; Erdmann, Jeanette; Nordestgaard, Børge G; Nielsen, Sune F; Tybjærg-Hansen, Anne; Sch...    »
 
Titel:
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. 
Abstract:
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying gene...    »
 
Zeitschriftentitel:
Science 
Jahr:
2016 
Band / Volume:
351 
Heft / Issue:
6278 
Seitenangaben Beitrag:
1166-71 
Sprache:
eng 
Print-ISSN:
0036-8075 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen