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Document type:
journal article 
Author(s):
Keenan, Tanya; Zhao, Wei; Rasheed, Asif; Ho, Weang K; Malik, Rainer; Felix, Janine F; Young, Robin; Shah, Nabi; Samuel, Maria; Sheikh, Nasir; Mucksavage, Megan L; Shah, Omar; Li, Jin; Morley, Michael; Laser, Annika; Mallick, Nadeem Hayat; Zaman, Khan Shah; Ishaq, Mohammad; Rasheed, Syed Zahed; Memon, Fazal-Ur-Rehman; Ahmed, Faisal; Hanif, Bashir; Lakhani, Muhammad Shakir; Fahim, Muhammad; Ishaq, Madiha; Shardha, Naresh Kumar; Ahmed, Naveeduddin; Mahmood, Khalid; Iqbal, Waseem; Akhtar, Saba; Rahe...    »
 
Title:
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. 
Abstract:
Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain.Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), ischemic stroke, and heart failure (HF).This study investigated 28 single nucleotide polymorphisms known to regulate serum urate levels in association with various vascu...    »
 
Journal title abbreviation:
J Am Coll Cardiol 
Year:
2016 
Journal volume:
67 
Journal issue:
Pages contribution:
407-16 
Language:
eng 
Print-ISSN:
0735-1097 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen