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Dokumenttyp:
journal article 
Autor(en):
Hensel, Tim; Giorgi, Chiara; Schmidt, Oxana; Calzada-Wack, Julia; Neff, Frauke; Buch, Thorsten; Niggli, Felix K; Schäfer, Beat W; Burdach, Stefan; Richter, Günther H S 
Titel:
Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma. 
Abstract:
Ewing sarcomas (ES) are highly malignant bone or soft tissue tumors. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic transcriptional program associated with altered epigenetic marks throughout the genome. By use of an inhibitor (JQ1) blocking BET bromodomain binding proteins (BRDs) we strikingly observed a strong down-regulation of the predominant EWS-ETS protein EWS-FLI1 in a dose dependent man...    »
 
Zeitschriftentitel:
Oncotarget 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1451-63 
Sprache:
eng 
TUM Einrichtung:
Kinderklinik und Poliklinik