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Dokumenttyp:
journal article 
Autor(en):
Bauernfeind, Franz; Niepmann, Sven; Knolle, Percy A; Hornung, Veit 
Titel:
Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances. 
Abstract:
Accumulating evidence suggests that the activation of the innate branch of the immune system plays a pivotal role in the induction and perpetuation of metabolic and aging-related diseases. In this context, the NLRP3 inflammasome pathway has been identified as an important driver of sterile inflammatory processes. De novo protein synthesis of NLRP3 induced by signals such as TLR ligands or TNF is a prerequisite for sustained NLRP3 mediated caspase-1 cleavage and inflammasome activation. Here, we...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2016 
Band / Volume:
197 
Heft / Issue:
Seitenangaben Beitrag:
2900-8 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Institut für Molekulare Immunologie