User: Guest  Login
Document type:
journal article 
Author(s):
Bauernfeind, Franz; Niepmann, Sven; Knolle, Percy A; Hornung, Veit 
Title:
Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances. 
Abstract:
Accumulating evidence suggests that the activation of the innate branch of the immune system plays a pivotal role in the induction and perpetuation of metabolic and aging-related diseases. In this context, the NLRP3 inflammasome pathway has been identified as an important driver of sterile inflammatory processes. De novo protein synthesis of NLRP3 induced by signals such as TLR ligands or TNF is a prerequisite for sustained NLRP3 mediated caspase-1 cleavage and inflammasome activation. Here, we...    »
 
Journal title abbreviation:
J Immunol 
Year:
2016 
Journal volume:
197 
Journal issue:
Pages contribution:
2900-8 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Molekulare Immunologie