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Document type:
journal article 
Author(s):
Ludwig-Portugall, Isis; Bartok, Eva; Dhana, Ermanila; Evers, Beatrix D G; Primiano, Michael J; Hall, J Perry; Franklin, Bernardo S; Knolle, Percy A; Hornung, Veit; Hartmann, Gunther; Boor, Peter; Latz, Eicke; Kurts, Christian 
Title:
An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. 
Abstract:
Intrarenal crystal formation activates the Nlrp3 inflammasome in myeloid cells and triggers a profound inflammatory response. Here, we studied whether a specific inhibitor of the Nlrp3 inflammasome, CP-456,773, can prevent kidney fibrosis in a murine model of crystal nephropathy induced by diets rich in oxalate or adenine. Inflammasome activation in renal dendritic cells and the resulting interleukin (IL)-1? and IL-18 production were markedly reduced by CP-456,773 treatment both ex vivo and in v...    »
 
Journal title abbreviation:
Kidney Int 
Year:
2016 
Journal volume:
90 
Journal issue:
Pages contribution:
525-39 
Language:
eng 
Print-ISSN:
0085-2538 
TUM Institution:
Institut für Molekulare Immunologie