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Dokumenttyp:
journal article 
Autor(en):
Morak, Monika; Käsbauer, Sarah; Kerscher, Martina; Laner, Andreas; Nissen, Anke M; Benet-Pagès, Anna; Schackert, Hans K; Keller, Gisela; Massdorf, Trisari; Holinski-Feder, Elke 
Titel:
Loss of MSH2 and MSH6 due to heterozygous germline defects in MSH3 and MSH6. 
Abstract:
Lynch Syndrome (LS) is the most common dominantly inherited colorectal cancer (CRC) predisposition and is caused by a heterozygous germline defect in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2. High microsatellite instability (MSI-H) and loss of MMR protein expression in tumours reflecting a defective MMR are indicators for LS, as well as a positive family history of early onset CRC. MSH2 and MSH6 form a major functional heterodimer, and MSH3 is an alternative binding p...    »
 
Zeitschriftentitel:
Fam Cancer 
Jahr:
2017 
Sprache:
eng 
Print-ISSN:
1389-9600 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie