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Document type:
journal article 
Author(s):
Mitran, Bogdan; Varasteh, Zohreh; Selvaraju, Ram Kumar; Lindeberg, Gunnar; Sörensen, Jens; Larhed, Mats; Tolmachev, Vladimir; Rosenström, Ulrika; Orlova, Anna 
Title:
Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26. 
Abstract:
Bombesin (BN) analogs bind with high affinity to gastrin-releasing peptide receptors (GRPRs) that are up-regulated in prostate cancer and can be used for the visualization of prostate cancer. The aim of this study was to investigate the influence of radionuclide-chelator complexes on the biodistribution pattern of the 111In-labeled bombesin antagonist PEG2-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (PEG2-RM26) and to identify an optimal construct for SPECT imaging. A series of RM26 analogs N-term...    »
 
Journal title abbreviation:
Int J Oncol 
Year:
2016 
Journal volume:
48 
Journal issue:
Pages contribution:
2124-34 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1019-6439 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik