User: Guest  Login
Document type:
journal article 
Author(s):
Zotz, Julia S; Wölbing, Florian; Lassnig, Caroline; Kauffmann, Marlies; Schulte, Uwe; Kolb, Andreas; Whitelaw, Bruce; Müller, Mathias; Biedermann, Tilo; Huber, Michael 
Title:
CD13/aminopeptidase N is a negative regulator of mast cell activation. 
Abstract:
Antigen-induced mast cell (MC) activation via cross-linking of IgE-bound high-affinity receptors for IgE (Fc?RI) underlies type I allergy and anaphylactic shock. Comprehensive knowledge of Fc?RI regulation is thus required. We have identified a functional interaction between Fc?RI and CD13 in murine MCs. Antigen-triggered activation of IgE-loaded Fc?RI results in cocapping and cointernalization of CD13 and equivalent internalization rates of up to 40%. Cointernalization is not unspecific, becaus...    »
 
Journal title abbreviation:
FASEB J 
Year:
2016 
Journal volume:
30 
Journal issue:
Pages contribution:
2225-35 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0892-6638 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie