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Dokumenttyp:
journal article 
Autor(en):
Steiert, Sabrina A; Zissler, Ulrich M; Chaker, Adam M; Esser-von-Bieren, Julia; Dittlein, Daniela; Guerth, Ferdinand; Jakwerth, Constanze A; Piontek, Guido; Zahner, Catherine; Drewe, Juergen; Traidl-Hoffmann, Claudia; Schmidt-Weber, Carsten B; Gilles, Stefanie 
Titel:
Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway. 
Abstract:
Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To...    »
 
Zeitschriftentitel:
Biofactors 
Jahr:
2017 
Sprache:
eng 
Print-ISSN:
0951-6433 
TUM Einrichtung:
Institut für Molekulare Allergologie und Umweltforschung