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Dokumenttyp:
journal article 
Autor(en):
Busche, Marc Aurel; Konnerth, Arthur 
Titel:
Impairments of neural circuit function in Alzheimer's disease. 
Abstract:
An essential feature of Alzheimer's disease (AD) is the accumulation of amyloid-? (A?) peptides in the brain, many years to decades before the onset of overt cognitive symptoms. We suggest that during this very extended early phase of the disease, soluble A? oligomers and amyloid plaques alter the function of local neuronal circuits and large-scale networks by disrupting the balance of synaptic excitation and inhibition (E/I balance) in the brain. The analysis of mouse models of AD revealed that...    »
 
Zeitschriftentitel:
Philos Trans R Soc Lond B Biol Sci 
Jahr:
2016 
Band / Volume:
371 
Heft / Issue:
1700 
Sprache:
eng 
Print-ISSN:
0962-8436 
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Neurowissenschaften