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Dokumenttyp:
journal article 
Autor(en):
Wörmann, Sonja M; Song, Liang; Ai, Jiaoyu; Diakopoulos, Kalliope N; Kurkowski, Magdalena U; Görgülü, Kivanc; Ruess, Dietrich; Campbell, Andrew; Doglioni, Claudio; Jodrell, Duncan; Neesse, Albrecht; Demir, Ihsan E; Karpathaki, Angelica-Phaedra; Barenboim, Maxim; Hagemann, Thorsten; Rose-John, Stefan; Sansom, Owen; Schmid, Roland M; Protti, Maria P; Lesina, Marina; Algül, Hana 
Titel:
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. 
Abstract:
One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and other solid tumors. We investigated whether loss of P53 function contributes to persistent activation of STAT3 and modification of the pancreatic tumor stroma in patients and mice.Stat3, Il6st (encodes gp130), or Trp53 were disrupted, or a mutant f...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2016 
Band / Volume:
151 
Heft / Issue:
Seitenangaben Beitrag:
180-193.e12 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik