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Dokumenttyp:
journal article 
Autor(en):
Jung, Sascha; Fischer, Jan; Spudy, Björn; Kerkow, Tim; Sönnichsen, Frank D; Xue, Li; Bonvin, Alexandre M J J; Goettig, Peter; Magdolen, Viktor; Meyer-Hoffert, Ulf; Grötzinger, Joachim 
Titel:
The solution structure of the kallikrein-related peptidases inhibitor SPINK6. 
Abstract:
Kallikrein-related peptidases (KLKs) are crucial for epidermal barrier function and are involved in the proteolytic regulation of the desquamation process. Elevated KLK levels were reported in atopic dermatitis. In skin, the proteolytic activity of KLKs is regulated by specific inhibitors of the serine protease inhibitor of Kazal-type (SPINK) family. SPINK6 was shown to be expressed in human stratum corneum and is able to inhibit several KLKs such as KLK4, -5, -12, -13 and -14. In order to under...    »
 
Zeitschriftentitel:
Biochem Biophys Res Commun 
Jahr:
2016 
Band / Volume:
471 
Heft / Issue:
Seitenangaben Beitrag:
103-8 
Sprache:
eng 
Print-ISSN:
0006-291X 
TUM Einrichtung:
Frauenklinik und Poliklinik