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Dokumenttyp:
journal article 
Autor(en):
Hermann, Michaela-Rosemarie; Jakobson, Madis; Colo, Georgina P; Rognoni, Emanuel; Jakobson, Maili; Kupatt, Christian; Posern, Guido; Fässler, Reinhard 
Titel:
Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion. 
Abstract:
Integrin-mediated activation of small GTPases induces the polymerisation of G-actin into various actin structures and the release of the transcriptional co-activator MRTF from G-actin. Here we report that pan-integrin-null fibroblasts seeded on fibronectin and expressing ?1- and/or ?V-class integrin contained different G-actin pools, nuclear MRTF-A (also known as MKL1 or MAL) levels and MRTF-A-SRF activities. The nuclear MRTF-A levels and activities were highest in cells expressing both integrin...    »
 
Zeitschriftentitel:
J Cell Sci 
Jahr:
2016 
Band / Volume:
129 
Heft / Issue:
Seitenangaben Beitrag:
1391-403 
Sprache:
eng 
Print-ISSN:
0021-9533 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik