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Dokumenttyp:
journal article 
Autor(en):
Stellos, Konstantinos; Gatsiou, Aikaterini; Stamatelopoulos, Kimon; Perisic Matic, Ljubica; John, David; Lunella, Federica Francesca; Jaé, Nicolas; Rossbach, Oliver; Amrhein, Carolin; Sigala, Frangiska; Boon, Reinier A; Fürtig, Boris; Manavski, Yosif; You, Xintian; Uchida, Shizuka; Keller, Till; Boeckel, Jes-Niels; Franco-Cereceda, Anders; Maegdefessel, Lars; Chen, Wei; Schwalbe, Harald; Bindereif, Albrecht; Eriksson, Per; Hedin, Ulf; Zeiher, Andreas M; Dimmeler, Stefanie 
Titel:
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. 
Abstract:
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRNA (CTSS), which encodes a cysteine protease associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. The 3' untranslated region (3' UTR) of the CTSS transcript co...    »
 
Zeitschriftentitel:
Nat Med 
Jahr:
2016 
Band / Volume:
22 
Heft / Issue:
10 
Seitenangaben Beitrag:
1140-1150 
Sprache:
eng 
Print-ISSN:
1078-8956 
TUM Einrichtung:
Klinik für Gefäßchirurgie