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Document type:
journal article 
Author(s):
Poschenrieder, Andreas; Schottelius, Margret; Schwaiger, Markus; Kessler, Horst; Wester, Hans-Jürgen 
Title:
The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity. 
Abstract:
The overexpression of the chemokine receptor 4 (CXCR4) in different epithelial, mesenchymal, and hematopoietic cancers makes CXCR4 an attractive diagnostic and therapeutic target. However, targeting the CXCR4 receptor with small cyclic pentapeptide-based radiopharmaceuticals remains challenging because minor structural modifications within the ligand-linker-chelate structure often significantly affect the receptor affinity. Based on the excellent in vivo properties of CXCR4-directed pentapeptide...    »
 
Journal title abbreviation:
EJNMMI Res 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
36 
Language:
eng 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik