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Dokumenttyp:
journal article 
Autor(en):
Friedrich, Teresa; Söhn, Michaela; Gutting, Tobias; Janssen, Klaus-Peter; Behrens, Hans-Michael; Röcken, Christoph; Ebert, Matthias P A; Burgermeister, Elke 
Titel:
Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. 
Abstract:
Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human cancers. Small DOK1 variants remain in cells of solid tumors and leukemias, albeit, their functions are elusive. To assess the so far unknown role of DOK1 in colorectal cancer (CRC), we generated DOK1 mutants which mimic the domain structure and subcellular distribution of DOK1 protein variants in leukemia patients. We found...    »
 
Zeitschriftentitel:
EBioMedicine 
Jahr:
2016 
Band / Volume:
Seitenangaben Beitrag:
159-72 
Sprache:
eng 
Print-ISSN:
2352-3964 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik