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Dokumenttyp:
journal article 
Autor(en):
Pastu?a, Agnieszka; Middelhoff, Moritz; Brandtner, Anna; Tobiasch, Moritz; Höhl, Bettina; Nuber, Andreas H; Demir, Ihsan Ekin; Neupert, Steffi; Kollmann, Patrick; Mazzuoli-Weber, Gemma; Quante, Michael 
Titel:
Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche. 
Abstract:
The gastrointestinal epithelium is characterized by a high turnover of cells and intestinal stem cells predominantly reside at the bottom of crypts and their progeny serve to maintain normal intestinal homeostasis. Accumulating evidence demonstrates the pivotal role of a niche surrounding intestinal stem cells in crypts, which consists of cellular and soluble components and creates an environment constantly influencing the fate of stem cells. Here we describe different 3D culture systems to cult...    »
 
Zeitschriftentitel:
Stem Cells Int 
Jahr:
2016 
Band / Volume:
2016 
Seitenangaben Beitrag:
3710836 
Sprache:
eng 
Print-ISSN:
1687-966X 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; Chirurgiesche Klinik und Poliklinik