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Dokumenttyp:
journal article 
Autor(en):
Tagawa, Takanobu; Albanese, Manuel; Bouvet, Mickaël; Moosmann, Andreas; Mautner, Josef; Heissmeyer, Vigo; Zielinski, Christina; Lutter, Dominik; Hoser, Jonathan; Hastreiter, Maximilian; Hayes, Mitch; Sugden, Bill; Hammerschmidt, Wolfgang 
Titel:
Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing. 
Abstract:
Epstein-Barr virus (EBV) is a tumor virus that establishes lifelong infection in most of humanity, despite eliciting strong and stable virus-specific immune responses. EBV encodes at least 44 miRNAs, most of them with unknown function. Here, we show that multiple EBV miRNAs modulate immune recognition of recently infected primary B cells, EBV's natural target cells. EBV miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of na...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2016 
Band / Volume:
213 
Heft / Issue:
10 
Seitenangaben Beitrag:
2065-80 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
Kinderklinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene